EXTENDED REPORT p53 in rheumatoid arthritis synovial fibroblasts at sites of invasion
نویسندگان
چکیده
C A Seemayer, S Kuchen, M Neidhart, P Kuenzler, V Řihošková, E Neumann, M Pruschy, W K Aicher, U Müller-Ladner, R E Gay, B A Michel, G S Firestein, S Gay . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
منابع مشابه
p53 in rheumatoid arthritis synovial fibroblasts at sites of invasion.
OBJECTIVE To analyse the functional response of p53 in rheumatoid arthritis synovial fibroblasts (RASF) in vitro and in vivo and to investigate whether activation of p53 modulates the destructive process of RASF. METHODS RASF and controls grown on chamber slides were either directly examined with DO7 anti-p53 antibodies by immunofluorescence or irradiated with 10 Gy x rays and analysed time d...
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INTRODUCTION Synovial fibroblasts invade cartilage and bone, leading to joint destruction in rheumatoid arthritis. However, the mechanisms that regulate synovial fibroblast invasion are not well understood. Focal adhesion kinase (FAK) has been implicated in cellular invasion in several cell types, and FAK inhibitors are in clinical trials for cancer treatment. Little is known about the role of ...
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We presented a female patient with RA complaining of progressive pain, swelling, and crepitation of the knee joints that was diagnosed with bilateral synovial chondromatosis (SC) of both knees. Radiographies revealed characteristic findings of SC including multiple calcified multifaceted loose bodies within both knees. Removal of cartilaginous segments as well as total synovectomy was performed...
متن کاملp53 in rheumatoid arthritis: friend or foe?
The knowledge of transcription factors and proto-oncogenes has influenced the understanding of cell regulation, cell cycle, and apoptotic cell death in rheumatoid arthritis (RA) synovium. In addition, the development of normal synovial fibroblasts into transformed-appearing aggressive synovial fibroblasts may be triggered by the lack of antiproliferative factors, such as p53, p53-associated mol...
متن کاملCommentary p53 in rheumatoid arthritis: friend or foe?
The knowledge of transcription factors and proto-oncogenes has influenced the understanding of cell regulation, cell cycle, amd apoptotic cell death in rheumatoid arthritis (RA) synovium. In addition, the development of normal synovial fibroblasts into transformedappearing aggressive synovial fibroblasts may be triggered by the lack of antiproliferative factors, such as p53, p53-associated mole...
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تاریخ انتشار 2003